Needle Free –
Needle-Free Injection System (NFIS) is one of the injection systems used to administer plasmid DNA vaccines.1, 2
Needle-free injectors for DNA vaccine delivery in clinical studies have been found to augment immune response, possibly by enhancing the dispersion of injecting substance.3
How Does the Needle-Free Injection System (NFIS) Deliver the Vaccine Intradermally?
It delivers the DNA vaccine into the cell via an intradermal route through a pressure device. The drug gets delivered between layers of the skin. Spring-powered injectors are used to deliver vaccine by means of a narrow stream of fluid that penetrates the skin in about 1/10 of a second.1, 2, 4
World’s First Needle-free COVID-19 Vaccine
ZyCoV-D® has to be administered only by the Needle-Free Injector System (NFIS) using the PharmaJet Tropis device.
Vaccine administration using NFIS device offers some distinct advantages compared to the conventional method of vaccination using needle and syringe:4, 6
Improved compliance and better coverage
No needle trash and needle stick injuries
Calibrated to reduce vaccine wastage
Automatically disables, no risk of reuse
Efficient vaccine delivery
What Makes Needle-Free Injection System (NFIS) a Suitable Choice?
The Needle-Free Injection System (NFIS) is unique compared to the traditional vaccine delivery methods like using a needle and syringe, in that it transfers the vaccine into the layers of skin (intradermal route).1, 2, 4 This makes the system more appealing to the people taking the vaccine as well as to the healthcare workers administering it.
Clinical Effectiveness of the Needle-Free Injection System (NFIS)?
Vaccines administered by the Needle-Free Injection System (NFIS) are reported to be as immunogenic as when given with needle and syringe. Studies have shown that NFIS is as effective in delivering the vaccine, as traditional needle and syringes are across children, adolescents and adults.